AstraZeneca and Meniscense showcase a technology collaboration to develop a novel interferometric technology for volume quantification, the technology promises the speed and accuracy needed to support high throughput production of nanoliter dispensed outputs. We share our results demonstrating the successful measurement of nanoliter droplets dispensed into dry wells and the volume change resulting from dispensed nanoliter droplets into a filled well. We discuss how this methodology will enhance the quality control process of a sample management or screening operation.