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Thursday, November 21 • 12:00pm - 12:30pm
Poster Presentation: Evaluation of Low mg Solid Dispenses to Support Acoustic Tube Platforms

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In preparation for a new workflow, Sample Management Boston identified a Tecan Fluent automation friendly tube for preparing DMSO solutions from neat stock. After evaluating the tube, it was determined that dry solid could be accurately dispensed to plastic tubes. The next part of the evaluation was to determine if small mg amounts could be dispensed to the tube accurately (between 0.15mg and 1.0 mg).
Nine AZ compounds were used in testing. They were a diverse mix of materials, ranging from powders to gums. On five place balances, each sample was dispensed 10 times to FluidX tubes. The dry dispenses were then solubilized to 10 mM and the solutions were measured by LCMS (10 mM + or – 10%) for concentration accuracy. Any solid dispense with a subsequent concentration between 9 - 11 mM was deemed accurate.

 The Achievement: The team demonstrated small amounts of solid compound can be accurately dispensed into the FluidX tube. Over 88% of all dispenses were accurate with concentrations between 9-11 mM (see table 1) The accuracy of dispenses around 0.35 mg of less was variable. Having the ability to dispense small amounts of dry sample accurately will allow AZ to conserve it’s solid compound collection.


Jeff Andrews

Sr Scientist, AstraZeneca
I've worked with the Sample Management Group at AstraZeneca since 2003. Some of my strengths within Sample Management are Customer Service and communications, Delivering on SLA’s (a focus on delivery customer requests correctly and on time) and Creative problem solving skills

Thursday November 21, 2019 12:00pm - 12:30pm EST
Essex North & Center (3rd Floor) - Westin Copley 10 Huntington Avenue, Boston, MA 02116 USA

Attendees (1)