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Session 2: Innovative Technology and Process Optimization [clear filter]
Wednesday, November 20
 

3:30pm EST

Innovative Technology and Process Optimization- Introduction
Chairs
CG

Christina Glazier

Senior Research Operations Manager, Amgen


Wednesday November 20, 2019 3:30pm - 3:35pm EST
Essex South (3rd Floor) - Westin Copley 10 Huntington Avenue, Boston, MA 02116 USA

3:35pm EST

Innovative Technology and Process Optimization- Living in a Simulation
The Amgen research environment is distributed around the world with a combination of staff and contract organizations. The Research Materials Management (RMM) organization is the hub in a hub-and-spoke model connecting compound producers with the consuming organizations. Discrete event simulation software was used to model current and proposed RMM processes and the resulting interaction with the downstream functions. In this talk I will discuss the lessons learned in simulation projects ranging from counting minutes in an automation heavy process to modeling the annual cost of outsourcing a specific task.

Co-Author: Julia Dookran, MS,  Engineer, Amgen

Speakers
avatar for Mark Gulbronson, MS, MA

Mark Gulbronson, MS, MA

Director Research Operations, Amgen
Mark Gulbronson, Director Research Operations, is head of Amgen’s Research Materials Management organization. With operations in California and Massachusetts, his team is responsible for the curation and worldwide distribution of Amgen’s small molecule and biologics collections... Read More →

Chairs
CG

Christina Glazier

Senior Research Operations Manager, Amgen


Wednesday November 20, 2019 3:35pm - 3:55pm EST
Essex South (3rd Floor) - Westin Copley 10 Huntington Avenue, Boston, MA 02116 USA

3:55pm EST

Innovative Technology and Process Optimization- Digital Innovation in Discovery Labs
BMS R&D IT has developed a ground-breaking solution using BonitaSoft BPM to provide agility, flexibility, and visibility across discovery organization like never before. BMS’s transformation into a BioPharma required an innovative approach to manage lab workflow across discovery organization. Traditional methods of managing lab workflows were rooted in LIMS that required significant and repeated customization to meet the needs of a continuously evolving R&D environment. Implementations of R&D BPM Framework based on BonitaSoft facilitated the digital transformation of analytical chemistry, vet sciences, histology, biologics, lead optimization, biomarkers, and lab equipment management across R&D. Multiple benefits were realized including:

· Time savings of 11,000 hours per year realized by discovery scientists.
· 50% reduction in application delivery time.
· The need for multiple custom solutions were eliminated resulting in cost savings estimated at $2MM.
· Increased transparency into lab processes.
· Access to on-demand live metrics.
· Simplified and consistent application support.

Co-Authors::
Viral, Vyas, MSIS, BMS
Yu-Sun Wang, , BMS

Speakers
VV

Viral Vyas, MSIS

Lead IT Business Partner Translational Medicine, Bristol Myers Squibb
Viral Vyas is a Lead IT Business Partner at Bristol Myers Squibb responsible for leading teams that deliver informatics capabilities to broad range of scientific stakeholders in the Translational Medicine organization. He received his undergraduate education in Microbiology and Masters... Read More →

Chairs
CG

Christina Glazier

Senior Research Operations Manager, Amgen


Wednesday November 20, 2019 3:55pm - 4:15pm EST
Essex South (3rd Floor) - Westin Copley 10 Huntington Avenue, Boston, MA 02116 USA

4:15pm EST

Innovative Technology and Process Optimization- Development and Implementation of a Business Process Management Platform to Transform High Throughput Biomolecule Production and Sample Management Workflows
Gene and protein production workflows are essential to the discovery of both small and large molecule therapeutics and a host of other research activities.  In order to keep pace with ever increasing requests to produce, manage and track large numbers of these critical reagents across multiple groups, the need arose to replace manual workflows and siloed informatics systems with a unified, automated request management and fulfillment platform able to be integrated with our registration and sample inventory management systems.  In this talk we will share how, through a highly collaborative effort between scientists and bioinformatics colleagues, we are developing an end-to-end request, workflow, registration and sample management solution which will increasingly enable a more efficient, high-capacity biomolecule discovery and production pipeline.

Speakers
KN

Kristen Nailor, B.S. Biochemistry

Scientific Manager, Genentech
Kristen Nailor holds  a degree in Biochemistry from Indiana University. She spent 7 years as a  medicinal chemist at GlaxoSmithKline. She then accepted a position as the  head of compound management at Vanderbilt University where she built a robust  compound management facility... Read More →

Chairs
CG

Christina Glazier

Senior Research Operations Manager, Amgen


Wednesday November 20, 2019 4:15pm - 4:35pm EST
Essex South (3rd Floor) - Westin Copley 10 Huntington Avenue, Boston, MA 02116 USA

4:35pm EST

Innovative Technology and Process Optimization- Optimizing Processes Using In-House Engineering to Innovate Automation and Sample Management
Sophisticated and often expensive automated solutions exist for a wide variety of laboratory processes in the sample management environment, however there remain many processes for which commercially available products do not exist or do not fully meet the needs of the end user. Fortunately, the rapid evolution of hardware and software tools over the past decade has made development of custom automation much more accessible for laboratory staff. The result of this evolution can be seen in many labs where technologies such as 3D printers and open source electronics platforms have become commonly utilized tools in the day-to-day operations of the lab.

The Lead Identification team at Scripps Florida is one such lab where these tools have been leveraged to address a wide variety of challenges in the Sample Management workspace. Use of these tools has resulted in the development of a number of unique devices including a custom microplate imaging platform, an open-source microplate illuminator and many other things. These have been integrated within our informatics infrastructure in a fashion which has quantitively impacted the efficiency of many processes in the lab by reducing staff workload and improving quality assurance. The advantages of developing in-house automation and lessons learned over a decade of doing so are presented.

Speakers
avatar for Pierre Baillargeon

Pierre Baillargeon

Senior Robotics Engineer, The Scripps Research Institute
Pierre is currently the Senior Robotics Engineer within the Lead Identification lab at Scripps Research where he supports Compound Management, High Throughput Screening, Assay Development and Informatics efforts by developing, assembling and integrating novel automated hardware and... Read More →

Chairs
CG

Christina Glazier

Senior Research Operations Manager, Amgen


Wednesday November 20, 2019 4:35pm - 4:55pm EST
Essex South (3rd Floor) - Westin Copley 10 Huntington Avenue, Boston, MA 02116 USA